I have translated it and will break out the main details in this post. Besides discussing his team’s scientific approach to hair regrowth, Mr. Kageyama also outlines their overall progress and future plans (though he gives on exact dates for clinical trials). Make sure to check out the diverse range of Google Scholar citations for Mr. Kagema. In most of his important hair growth related papers, he is a co-author with Dr. Fukuda and others.
Previously, I also mentioned that Ayaka Nanmo, Tatsuto Kageyama and Junji Fukuda are co-founders of a new company named TrichoSeeds. It aims to provide “hair regeneration medicine.”
Bioengineering Approaches for Hair Regeneration
To start off, Mr. Kageyama outlines the three main methods of hair regeneration that his team at Fukuda Lab is working on:
Hair follicle primordium transplantion. See their pending patent on hair follicle primordia.
Hair follicle regeneration. The creation of brand new hair follicles in those who have none left. See their January 2024 study on the large-scale preparation of hair follicle germs (HFGs). The transplantation of HFGs in mice resulted in highly efficient “de novo” hair follicle regeneration.
Bioengineering Approaches to Hair Regeneration. Journal of the Society of Bioengineering Volume 102, Issue 4 (2024). Tatsuto Kageyama.
I am most excited about the first method for now since it will come to market first. Especially in aging Japan, where autologous regenerative medicine treatments are going to be speed tracked to in-clinic use. In fact in my recent post titled “A Visit to Fukuda Lab“, Dr. Junji Fukuda had the following quote:
“Dermal papilla cell transplantation is about to begin in Japan.“
If you have a reasonable amount of your own scalp hair remaining, this mesenchymal stem cell injection treatment sounds very promising. The diagram below that Mr. Kageyma published in his new paper is extremely detailed.
Techniques for Culturing Dermal Papilla Cells
Mr. Kageyama discusses his team’s three unique approaches to culturing dermal papilla cells. I covered these methods in various posts and updates related to Dr. Junji Fukuda’s published papers over the past decade.
The conventional dermal papilla culturing method (number 1 below) is similar to Shiseido’s work, which Mr. Kageyama discusses briefly. He says that it has limited effectiveness, since the hair regeneration ability of the cells is reduced during the process of growing mesenchymal cells in a culture dish.
Conventional culturing.
Gel bead culture.
Electrical stimulation culture.
Startified culture.
Mesenchymal stem cell culturing and injection of derma papilla cells for hair growth. Journal of the Society of Bioengineering Volume 102, Issue 4 (2024). Tatsuto Kageyama.
Hair Regeneration by Transplantation of Hair Follicle Primordia
In this second key approach, the aim is to increase the total number of existing hairs. Dr. Kageyama also discusses the work of Dr. Takashi Tsuji and his team in this section of the paper.
The gist of this technology is the mixing of epithelial cells and mesenchymal cells into a single aggregate. This in turn results in the formation of hair follicle primordia (hair seeds), which can then be transplanted into thinning areas of the scalp. The Fukuda team has already succeeeded in the large-scale preparation of hair follicle primordia.
At present, the team is conducting experiments in transplanting human hair follicle primordia into mice and improving the regeneration efficiency. At present, there is no guarantee that hair follicle will regenerate from the transplanted seeds. It is also difficult to control the direction of new hair growth with this approach.
Hair Follicle Regeneration
The third and final approach entails the creation of brand new hair follicles for transplantation. i.e., hair multiplication. The Fukuda Lab team has managed to develop a culturing technique for regenerating hair follicles in vitro. The discussion here is fairly technical, so I will just quote (and hope that the translation is accurate):
“Focusing on the self-organization process of epithelial cells and mesenchymal cells, we regenerate mature hair follicles with high efficiency (>99%) by controlling the spatial arrangement pattern of aggregates that form in the early stage of culture. Controlling the spatial arrangement of epithelial cells and mesenchymal cells in the aggregate on the second day of culture from a dumbbell shape to a core-shell shape was the key to in vitro hair regeneration. The production method is very simple, such as adding approximately 2% Matrigel to the culture medium when seeding epithelial cells and mesenchymal cells.”
Hair Follicle Regeneration In Vitro. Journal of the Society of Bioengineering Volume 102, Issue 4 (2024). Tatsuto Kageyama.
Future Plans
The team plans to continue its work in all three approaches to hair regeneration. i.e., transplantation of mesenchymal cells, transplantation of hair follicle primordia, and transplantation of regenerated hair follicles. Moreover, they have succeeded in constructing microtweezers that can grasp, cryopreserve, and eject hair follicle primordia. They are also working with robotics experts to develop a fully automated transplantation robot.
Learn more at http://curemydisorder.com/links/dht-blocker-for-hairloss
Olá a todos! Estou a pensar em começar a fazer apostas desportivas, mas entre os muitos sites não consigo decidir qual é o melhor para começar. Que critérios devem ser tidos em conta na escolha? E alguém tem experiência com plataformas específicas?
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Oxytocin (OXT) is better known as the “love hormone”. It is produced and released by women during childbirth and lactation. It is also produced during skin stimulation, such as when hugging or getting a massage. OXT is also called the anti-stress hormone.
In this study, OXT treatment resulted in the upregulation of genes that were associated with hair growth promoting factors. These included VEGFA (a protein encoded by the VEGF gene), PDGFB, FGF7 and BMP2. This ultimately results in peg-like hair sprouting via the improved hair growth ability of dermal papilla cells.
Oxytocin and Hair Growth. Source: Nature, 20 October, 2023. Fukuda et al.
Oxytocin, Cinnamic Acid and Hair Growth
I was 50/50 about writing a post on oxytocin and hair growth. We have seen numerous such past unusual examples that ultimately lead to no actual hair loss products.
However, in February 2023, the same researchers from Japan published yet another study that found cinnamic acid to promote hair growth via the activation of oxytocin receptor (OXTR) expression. Cinnamon is officially known as Cinnamomum cassia, and cinnamic acid is a component of Cinnamomum cassia.
“Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human dermal papilla (DP) cells.”
Three people e-mailed me the story about these findings that was published on phy.org several weeks ago. And a few others also posted blog comments about this news. No-one seemed to connect both these Japanese studies if I recall correctly.
Cinnamic Acid, Oxytocin Receptor Activation and Hair Growth. Source: Nature, 27 February, 2024. Fukuda et al.
Note that cinnamic acid can also be derived naturally from a number of plants. The most famous being cinnamon, shown in the image above. Yet one more ingredient to add in the list of natural treatments for hair loss.
A 2012 study from Japan found that cinnamon extract promotes Type I collagen biosynthesis via the activation of IGF-I signaling in human dermal fibroblasts. Also from 2012, a study from Taiwan concluded that cinnamic aldehyde (a constituent of Cinnamomum cassia) has excellent anti-inflammatory properties.
Oxytocin (OXT) is better known as the “love hormone”. It is produced and released by women during childbirth and lactation. It is also produced during skin stimulation, such as when hugging or getting a massage. OXT is also called the anti-stress hormone.
In this study, OXT treatment resulted in the upregulation of genes that were associated with hair growth promoting factors. These included VEGFA (a protein encoded by the VEGF gene), PDGFB, FGF7 and BMP2. This ultimately results in peg-like hair sprouting via the improved hair growth ability of dermal papilla cells.
Oxytocin and Hair Growth. Source: Nature, 20 October, 2023. Fukuda et al.
Oxytocin, Cinnamic Acid and Hair Growth
I was 50/50 about writing a post on oxytocin and hair growth. We have seen numerous such past unusual examples that ultimately lead to no actual hair loss products.
However, in February 2023, the same researchers from Japan published yet another study that found cinnamic acid to promote hair growth via the activation of oxytocin receptor (OXTR) expression. Cinnamon is officially known as Cinnamomum cassia, and cinnamic acid is a component of Cinnamomum cassia.
“Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human dermal papilla (DP) cells.”
Three people e-mailed me the story about these findings that was published on phy.org several weeks ago. And a few others also posted blog comments about this news. No-one seemed to connect both these Japanese studies if I recall correctly.
Cinnamic Acid, Oxytocin Receptor Activation and Hair Growth. Source: Nature, 27 February, 2024. Fukuda et al.
Note that cinnamic acid can also be derived naturally from a number of plants. The most famous being cinnamon, shown in the image above. Yet one more ingredient to add in the list of natural treatments for hair loss.
A 2012 study from Japan found that cinnamon extract promotes Type I collagen biosynthesis via the activation of IGF-I signaling in human dermal fibroblasts. Also from 2012, a study from Taiwan concluded that cinnamic aldehyde (a constituent of Cinnamomum cassia) has excellent anti-inflammatory properties.
My friends from the USA, tell me, please, have you had the chance to do sports with a coach online? I’ve been planning to do stretching online with this experienced coach for a long time https://flexderek.com/en/stretchingonline/ But I can’t bring myself to do it because I need constant total control. What do you think about this? What can you tell me about training online?
Author, are you considering individual or group stretching classes? My friend works out almost every day online with a fitness trainer and she is satisfied with this format of classes.
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The example below is from a total 3500 graft case.
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I have covered most of the World Congress for Hair Research annual meets that have occurred since 2013. The 13th edition of the World Congress for Hair Research takes place from April 6-9, 2024 in Dallas, Texas.
13th World Congress for Hair Research
The 13th World Congress for Hair Research (#WCHR2024) takes place from April 6-9, 2024 in Dallas, Texas. You can check out the official hair2024 website for more information. It is organized by the American Hair Research Society (AHRS) and the sister societies of the International Federation of Hair Research Societies.
13th World Congress for Hair Research. And a Total Solar Eclipse.
Due to the total Solar Eclipse that will take place across North American on April 8, the organizers have run with that theme and logo. Interestingly, Dallas (and much of Texas) will be among the best places for viewing the eclipse.
The final Full Program Guide is very interesting. Dozens of globally renowned hair loss researchers are presenting. Among the especially well known ones that I have covered numerous times on this blog include: Dr. Cheng Ming Chuong; Dr. Angela Christiano; Dr. George Cotsarelis; Dr. Rachita Dhurat; Dr. Luis Garza; Dr. Claire Higgins; Dr. Mayumi Ito; Dr. Colin Jahoda; Dr. Manabu Ohyama; Dr. Ralf Paus; and Dr. Sergio Vano Galvan.
There are numerous presentations of special interest to us, including on: stem cells; low-dose oral Minoxidil; regenerative medicine; biologics; follicle cryopreservation; mesenchymal-epithelial interactions; iPSCs; and hair graying. Of course there are also numerous hair transplant related sessions, workshops and discussions.
Make sure to check out the American Hair Research Society’s social media channels for updates:
Interestingly, Cosmo Pharmaceuticals’ key partner Sun Pharma is a Gold level sponsor of this conference. Perhaps further evidence that Breezula will be on the market in 2026 as expected.
Learn more at http://curemydisorder.com/links/dht-blocker-for-hairloss
Online stretching classes
